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Fairbanks 2008): Autoimmune hepatitis: an autoimmune disease in which the immune system attacks the bodys own hepatocytes Cholestatic liver diseases (diseases that interfere with the production or flow of bile), such as: Primary biliary cirrhosis: a chronic and slowly progressive inflammatory liver disease that is thought to be autoimmune in origin and results from damage to the small bile ducts Primary sclerosing cholangitis: a condition often associated with inflammatory bowel disease that results in inflammation and fibrosis, which causes narrowing and dilation of the intrahepatic and extrahepatic bile ducts Cystic fibrosis: an inherited condition characterized by thick secretions that mainly affect the lungs, pancreas, intestines, and liver Biliary atresia: congenital malformation of bile ducts Inherited metabolic disorders , such as: Alpha-1 antitrypsin deficiency: a genetic disease that can cause chronic liver disease, cirrhosis, and hepatocellular carcinoma Wilsons disease: an inherited copper storage disease Hereditary hemochromatosis: iron storage disease Glycogen storage diseases: excessive liver storage of glycogen Abetalipoproteinemia: inability to synthesize certain lipoproteins and to absorb fats and fat-soluble vitamins Budd-Chiari syndrome: thrombosis (clotting) of liver blood vessels 6 Diagnosis Clinical Signs and Symptoms Clinical signs and symptoms of cirrhosis include (NIDDK 2014a