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Despite the incredible advancements in wound care and regenerative medicine, key agenciesincluding the Centers for Medicare & Medicaid Services (CMS), the Food and Drug Administration (FDA), and the Agency for Healthcare Research and Quality (AHRQ)still lack a unified, standardized definition of what constitutes a "skin substitute." They actually rely on a list of surgical procedures to define products, The CPT manual, which explicitly states it does define products

However, when ASP is reported, it may serve as a better estimate of cost across both settings as the ASP reflects sales to physicians as well as hospitals

Published research indicates that this protection is substantial

Restart timing remains unsettled because trials have not measured re-titration after a prolonged stop