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The most commonly used drugs are aminosalicylates, corticosteroids (CS), immunomodulators (for example, thiopurines (TPs), methotrexate (MTX), calcineurin inhibitors, Janus kinase (JAK) inhibitors) and biologics drugs

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An increase might have been observed in the tibial area bone mineral density (BMD, which is the ratio of BMC to area), but the total and vertebral area BMDs seem to have remained consistent

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The choice of solvent and the method of reconstitution are critical