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Significance was determined by unpaired two-tailed Students t -test ( e , f ) and two-way ANOVA with Tukeys multiple comparison test ( h , i )

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Mice undergoing in vivo reprogramming were found to become depleted in B 12 and show signs of methionine starvation while supplementing reprogramming mice and cells with B 12 increased reprogramming efficiency, indicating a cell-intrinsic effect

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