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The effects of low GSH can lead to a laundry list of unwanted medical conditions and disease states

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The switch between production of eumelanin and pheomelanin depends on the strength of MC1R signaling and the availability of the amino acid cysteine

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202,203 Essentially, the imported disulphide-containing proteins undergo cathepsin-catalysed degradation in the lysosome, leading to the formation of cystine, which is then effluxed by the cystinosin transporter into the cytosol, where it is reduced to cysteine in a process that requires NADPH, leading to the formation of oxidised glutathione