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Although the statistical evaluation of several of these "studies" were inadequate with some reports presenting only "clinical impressions," all investigators noted some improvement in cognitive function and positive effects of neuropsychological parameters in elderly patients with dementia subsequent to the administration of acetyl-L-carnitine [117]

These benefits, along with already widespread use and generally good tolerability profile, have piqued interest in the potential benefit of SGLT2i and GLP1-RA in patients with rheumatologic conditions, who are at higher risk of cardiovascular and renal complications

We believe it has become clear that GLP-1s alone are not the answer due to side effects, poor adherence, and loss of muscle mass, said Gaur

These mechanisms of action, whilst therapeutically beneficial, can impact nutritional intake