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The charged nature of GSH (negative at physiological pH) suggests that GSH cannot passively diffuse into the mitochondria, because the mitochondrial matrix has a negative potential relative to the cytoplasm

K., Othman, H

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To date, studies in animals and humans suggest that GLP-1 may improve hepatic lipid accumulation through signal transduction of the AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway [33]

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