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Whenever GH needs to be secreted (GH levels are typically highest during periods of fasting and sleep), the hypothalamus releases growth hormone-releasing hormone (GHRH)

The combined effect is better blood sugar control and a significant reduction in appetite, leading to decreased food intake and, often, weight loss

Caitlin Beale, MS, RDN Tester Caitlin Beale, MS, RDN, is a registered dietitian and freelance health writer with experience in clinical nutrition, education, research, and private practice

Nasal delivery is the least-established route , with emerging interest for neurological and brain-adjacent applications, but limited human data to date