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Compared to age-matched controls, insulin resistance in the brains of PD patients is independent of peripheral insulin resistance and manifests as severe abnormalities in brain insulin signal transduction

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As with a majority of drugs, there are also adverse side effects to these weight-loss drugs, namely nausea, diarrhea, vomiting, constipation, among others

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Individual responses depend on dosing, timing of administration, and underlying medical conditions like diabetes or hypertension