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The FDA also recommends examining hard clinical endpoints such hepatic decompensations, transplant free survival, and all-cause mortality, although these results are not necessarily needed prior to drug approval given the long length of follow up potentially required

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2A R antagonists can improve motor dysfunction in patients with PD as monotherapy or in combination with L-DOPA and other antiparkinsonian drugs (Table 1) [57,58]

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However, we did observe higher increases in serum calcitonin levels, a tumor marker for medullary thyroid carcinoma, with increased doses of tirzepatide compared to placebo

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