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Third, and more speculatively, weight loss was perhaps considered an unserious reason to take a drug, more a question of willpower than pharmacology

However, melatonin is not exclusively produced in the pineal gland, but it is also locally synthesized in several cells and tissues, such as the retina, the gastrointestinal tract, and the innate immune system 10

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So when people promote microdosing, theyre extrapolating from theory and small observational experiences rather than robust randomised data