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The frameworks crystallinity and chemical stability, confirmed by PXRD and FT-IR analyses, ensure structural integrity during systemic circulation, while TGA data validate controlled thermal decomposition profiles for sustained release applications [139]

And its constitutive over-activation, with canonical signaling pathways containing effector molecules such as STAT3/5, PI3K-AKT, and RAS-MAPK activating, which induce malignant phenotype and promoting tumorigenesis, has been implicated in the progression of multifarious cancers (Fukushima et al., 2018)

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The pretreatment with ebselen significantly increased the survived SGN numbers, inhibited the apoptosis, and enhanced the expression of 4-HNE in the cultured SGNs of peroxynitrite + ebselen group compared with the peroxynitrite-only group