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Primarily, it suppresses ovarian theca cell proliferation via mevalonate pathway inhibition, achieved through transcriptional downregulation and enzymatic suppression of HMG-CoA reductasethe rate-limiting enzyme in cholesterol biosynthesis (86)

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If these symptoms persist, providers may recommend maintaining therapy at the previously tolerated dose while they investigate the potential for underlying issues

Discussion Causality assessment and differential diagnosis We applied the Roussel Uclaf Causality Assessment Method (RUCAM) to evaluate the causal relationship between each suspected drug and DILI

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