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Pal-GHK has also been suggested to be influential in reducing redness and discolored skin following photodamage (melasma) in animal models

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Part of this fascination stems from its association with the pineal gland often called the "third eye" due to its role in circadian rhythms and part from an extensive body of research dating back to the 1980s

This activation significantly increased the Bcl-2-associated X protein (Bax)/B-cell lymphoma 2 (Bcl-2) ratio and cysteine-aspartate protease 3 (Caspase-3) expression, inhibited GPX4 and quinone oxidoreductase 1 (NQO1) expression, increased MDA levels, and promoted apoptosis, ferroptosis, and lipid peroxidation in NSC-34 cells