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Thus, it is possible that the combination of low GH and normal IGF-I serves as a physiological mechanism aimed at preserving the GH/IGF-I anabolic effects and minimizing the insulin-antagonistic effects of GH without compromising the positive IGF-I metabolic effects

10.2337/diabetes.53.5.1326 [DOI] [PubMed] [Google Scholar] 44.Aulinger BA, Bedorf A, Kutscherauer G, de Heer J, Holst JJ, Gke B, et al

project management: AG

In the STEP 1 trial extension, participants regained roughly two-thirds of what they had lost after stopping semaglutide (sold as Wegovy for weight management)