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2.2 Study inclusion and exclusion criteria Studies eligible for inclusion were peer-reviewed English journal articles, reviews, or meta-analyses published between 2020 and 2025
Doses ranging from 5 to 10 grams have been most commonly studied in human trials, though these investigations primarily focused on glycemic control rather than GLP-1 secretion as a primary endpoint
Activation of 3-AR via Gs cAMP PKA phosphorylation of hormone-sensitive lipase (HSL) leads to: Splitting of triglycerides into free fatty acids + glycerol Release of fatty acids from adipose tissue into the blood Increased oxidation of fatty acids in mitochondria (muscle, liver) Heffernan et al
Ascorbic acid (Vitamin C) 20 mg
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