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The obstruction occurred after a reasonable exposure window , often within months of dose escalation or prolonged use

The timeline and criteria for such a decision have not been formally specified, but the conversation in elite sports circles is active

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In this trial, only vitamin E met the prespecified significance level of the primary outcome (i.e., improvement in histological findings, which included an improvement in hepatocellular ballooning), although both active treatment groups had a significant reduction in steatosis, lobular inflammation, and NAS (NAFLD activity score)