However, retatrutide is not yet FDA-approved and is only available through clinical trials or research channels
Therefore, compound 36 (Figure 5) was determined to be a reliable lead for designing new compounds with anti-diabetic activities
Dis Mon 69(5):101557 Puri TA, Lieblich SE, Ibrahim M, Galea LA (2024) Pregnancy history and estradiol influence spatial memory, hippocampal plasticity, and inflammation in middle-aged rats
It is derived from exendin-4 through N-terminal truncation and shares 53% sequence homology with native GLP-1 39
10.1111/dom.12802 Summary Keywords type 2 diabetes, DPP-4 inhibitors, oral antidiabetic, incretin-based therapy, gliptin, combination therapy Citation Gallwitz B (2019) Clinical Use of DPP-4 Inhibitors