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2 Tumor-associated macrophages: an in-depth analysis The traditional belief that tumor-associated macrophages (TAMs) solely originate from bone marrow monocytic progenitors has evolved substantially in recent years ( 2.1 Diversity and classifications of TAM The diverse origins and functional variability of TAMs ( Figure 2 ) pose considerable difficulties for their ontological classification ( Figure 2 2.2 Macrophage polarization states and their distinctive properties Macrophages exhibit remarkable heterogeneity and adaptability, rapidly responding to environmental cues by polarizing into functionally distinct phenotypes

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Additionally, UC is associated with a decrease in SCFAs, particularly butyrate, which are crucial for maintaining intestinal health

Group II (Intermittent Fasting Group): This set of animals (15 rats, 5 rats/cage) underwent an alternate-day fasting regimen in which they were given free access to food for 24 h and then disallowed for the next 24 h

Most of it resolves as the dose titrates