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It is a peptide that has been studied for possible effects on sleep regulation, especially deep sleep or delta-wave sleep

RIBBON-2: A randomized, double-blind, placebo-controlled, phase III trial evaluating the efficacy and safety of bevacizumab in combination with chemotherapy for second-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer

However, it did not lead to a fall in the development of heart failure or a repeat myocardial infarction (MI)

[24] In that study, fatigue was found to be a major symptom in hypothyroidism