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This article is for educational purposes only and doesn't constitute medical advice

Given the many unknowns with high dose folic acid supplementation, particularly unmetabolized folic acid (as covered in my folate article), Im not able to draw any strong conclusions here

The simpler same-day approach wins for most people purely because it is easier to remember, and consistency beats cleverness when the whole protocol depends on you taking the doses

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Tang, Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism, Nature, vol