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During sleep, cerebrospinal fluid (CSF) flows through brain tissue, helping remove metabolic waste products and proteins that accumulate throughout the day

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Xu G, Hansen JS, Zhao XJ, Chen S, Hoene M, Wang XL, et al

But in contrast to fructose, the human genome does not encode for enzymes that are able to metabolise allulose leading to an almost complete renal excretion of the absorbed dose and near-to-zero energetic yield

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