The association of APR-246 with induction of ferroptosis (either by pharmacological compounds, or genetic inactivation of SLC7A11 or GPX4) had a synergistic effect on the promotion of cell death, both in vivo and ex vivo
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Receptors and Functions of GLP-1 and -2 Both GLP-1 and -2 are co-encoded by proglucagon which is a 180-amino acid precursor with five individually processed domains
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In cancer cells, cysteine deficiency blocks GSH synthesis and, consequently, the activity of GPX4 and its capacity to suppress ferroptosis is impaired
