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Mechanistic Insights & Splice-Variant Biology Mechanistic research indicates that the E-domain (C-terminal) region of IGF-1Ec may localize to nuclei, modulate transcriptional responses, and influence cell survival pathways distinct from traditional IGF-1 signaling

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It has been reported to cause jaundice, fulminant hepatitis, subacute hepatic necrosis, cholestatic hepatitis and acute liver failure [216,217]

They are found in foods such as meats, fish, and soybeans

A few years after publishing their data, the same researchers repeated their experiments