Another important white space is represented by the emergence of comorbidity-driven positioning of oral obesity drugs, which allows marketing such medicines as treatment not only for weight loss but also for obesity associated with type 2 diabetes, cardiovascular risks, metabolic syndrome, and MASH
Notably, tirzepatide 15 mg was superior to semaglutide 1 mg in lowering A1c in a trial (SURPASS-2), reflecting the added GIP action
And TRANSCEND-T2D-1, part of a separate three-trial diabetes-specific program, confirmed -2.0% HbA1c reduction and 16.8% weight loss in 537 type 2 diabetes patients (topline March 2026, published in The Lancet, June 2026)
Creating a calming bedtime routine like reading, meditating, or limiting screen time can make a big difference
The smell of frying meat or heavy spices can trigger vomiting before you even sit down to eat