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Synthesis of the 2,2-(propane-2,2-diylbis(sulfanediyl))bis(ethan-1-ol) The 2,2-(propane-2,2-diylbis(sulfanediyl))bis(ethan-1-ol) was synthetized using a similar procedure as previously reported 48

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The two reasons are that CBS is activated by estradiol and betaine (Bet), which is twice as high in females compared to males because the enzyme PEMT [Figure 1] is activated by a factor of 2.3 in menstruating females