Here is the standard escalation for both formulations: Sources: Ozempic FDA prescribing information (2025), Wegovy FDA prescribing information
Gut Health on Weight Loss Medications Looking after your gut health is crucial for feeling your best on these medications
You should contact your GP or diabetes care team if: Cold sensitivity is severe, persistent, or progressively worsening You experience cold intolerance accompanied by other symptoms such as extreme fatigue, constipation, dry skin, hair loss, or unexplained weight gain You develop symptoms suggestive of hypothyroidism (underactive thyroid), which can cause cold sensitivity (note that while GLP-1 receptor agonists have been associated with C-cell tumours in rodent studies, there is no established link to hypothyroidism in humans) You notice signs of anaemia, such as pallor, breathlessness, or palpitations, which can cause cold sensitivity Cold hands or feet are accompanied by colour changes (white, blue, or red), pain, or numbness, which may indicate circulatory problems You experience unexplained fever, chills, or rigors, which could suggest infection You have symptoms of hypoglycaemia (low blood sugar) such as shakiness, sweating, or confusion, especially if you also take insulin or sulfonylureas NICE guidance (NG28) recommends regular monitoring of patients on GLP-1 receptor agonists, including assessment of glycaemic control, weight, and tolerability
Recently, Semaglutide has been approved by the FDA for weight loss in obese and certain overweight patients
Overdose If you or anyone else accidentally takes more WEGOVY 1MG INJECTION, consult your doctor immediately or visit the nearby hospital
