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The broad search algorithm combined index terms and free-text words for all GLP-1-RAs, with no restriction to study language, design (including both individual studies and their meta-analyses), setting, comparator and outcome of interest to maximize the comprehensiveness of the evidence synthesis

Cost: Higher than topical approaches but potentially more cost-effective per result due to improved efficacy

Researchers may investigate its role in maintaining cellular redox balance, supporting enzymatic activity, and influencing molecular interactions within experimental models

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