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A deficiency can lead to these symptoms

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By inhibiting the reuptake of these neurotransmitters, they are more present around cells

Activated PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3), which functions as a second messenger, recruiting AKT and PDK1 to the plasma membrane

Koppe L, Pillon NJ, Vella RE, Croze ML, Pelletier CC, Chambert S,