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These diseases can significantly impact a persons quality of life, making it essential to address inflammation as part of both prevention and treatment strategies

331 DR is closely associated with stroke 332,333,334,335,336 and cerebral microangiopathy

1 2 Drug Discovery: A History

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We propose that hepatic activation of TH signaling has insulinotropic and glucose-lowering effects, as it is able to increase non-12-OH FXR-antagonistic BA levels through shaping the BA composition by repressing hepatic CYP8B1, thereby enhancing the GLP-1 production via suppressing intestinal FXR signaling