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The difference is receptor responsiveness

This review intends to explore the molecular mechanisms underlying ferroptosis in the development and progression of osteoporosis, focusing on elucidating the three-dimensional regulatory network involving iron metabolism disorders, lipid peroxidation, and imbalances in bone homeostasis

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Similarly, AtPDF2.6 overexpression also enhanced Cd tolerance, while its knockout increased Cd sensitivity, emphasizing its role in detoxification via chelation and efflux (Luo et al., 2019)