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Science 317 , 666670 (2007)

In addition, knock-down of Gsta4 in differentiated OLs had the opposite effect, with an increase in mitochondrial levels of Casp8 and Bid (Fig

The resulting disulfide in the Grx active site, however, is not reduced by a dedicated reductase, but by two molecules of GSH that reduce the Grx via a Grx active site and GSH (Grx-S-SG) mixed disulfide intermediate (Figure 1)