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Although the studies testing the effect of urolithin A on the circadian clock included in this review (3335) did not include sleep-related outcomes, central clock gene oscillations in the SCN govern sleepwake cycles and are, therefore, mechanistically relevant to sleep

Patients routinely fly in to be evaluated by COEM, as we serve patients nationally and internationally

Genetic redundancy within the pathway Given the genetic complexity of the pathway (Table 1), gene-specific Arabidopsis mutants have been very useful in defining the importance of the different isoforms

This is about resolving a deficiency rather than enhancing cognition beyond normal

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