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The subcutaneous fat layer tends to be thickest here, making it easier to get a clean injection into fatty tissue without accidentally going too deep into muscle

Glucose-dependent insulinotropic polypeptide (GIP) is the other major incretin hormone (13)

Where semaglutide, a GLP-1-only agonist, produces roughly 15% body weight loss on average, tirzepatide pushes past 20%

Clinical trials show that gastrointestinal side effects, including diarrhea, peak in the first 24 weeks after starting tirzepatide and again when your dose increases

Key takeaways Theres no official tirzepatide diet plan, but eating balanced, nutrient-dense meals helps maximize results, reduce side effects, and support sustainable weight loss