Indeed, steroids role and their effect on ICI therapy remain an evolving space with many discrepancies [72]
GIP (Glucose-dependent Insulinotropic Polypeptide): Another incretin hormone produced in the intestines Stimulates insulin secretion from the pancreas Enhances fat metabolism Affects how the body stores and uses energy May amplify the appetite-suppressing effects of GLP-1 The Combined Effect: When both GLP-1 and GIP pathways are activated together: Stronger insulin response: better blood sugar control Enhanced fat burning: greater weight loss More appetite suppression: reduced food intake Slower gastric emptying: prolonged fullness (and potential problems) Clinical Advantages of Tirzepatide Greater Weight Loss: Clinical trials showed tirzepatide produced: Average weight loss: 20-25% of body weight Compared to semaglutide: 15-20% Some patients lost 30%+ of their starting weight Faster Results: Many patients report: Quicker onset of appetite suppression More rapid weight loss in the first months Stronger fullness sensation after meals Superior Glucose Control: For diabetic patients: Greater A1C reductions than semaglutide More patients reaching target A1C goals Fewer patients needing additional diabetes medications Potential Disadvantages and Risks 1
Combining natural compounds with adjuvants or using them as an adjunct to conventional treatment are promising strategies to optimize outcomes (Sakshi et al., 2023)
doi: 10.3389/fphar.2025.1718803 Received 04 October 2025 Revised 07 November 2025 Accepted 10 November 2025 Published 26 November 2025 Volume 16 - 2025 Edited by Giuseppe Remuzzi, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Italy Reviewed by Muhammad Saboor, University of Sharjah, United Arab Emirates Ferruh Artunc, University of Tbingen, Germany Updates Copyright 2025 Deng, Gong, Huang, Zhou and Ren
They enhance tendon healing, reduce inflammation, and strengthen connective tissue, especially when combined with PRP or exosomes
