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In certain embodiments, the subject may be a subject having a baseline intracellular level of GSH, tGSH, or both, when compared to children without a diagnosis of autism (it has previously been found that plasma, intracellular, and even brain levels of GSH may be decreased compared to control children without autism

GSH levels were quantified by a colorimetric approach using a diagnostic kit (Glutathione Assay kit, Calbiochem, San Diego, CA, USA)

Discussion To our knowledge, this is the first study to demonstrate an increase in CNS GSH levels with a noninvasive GSH augmentation strategy

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322 However, a randomized Phase 2 clinical trial of KGF in patients with ARDS revealed that VFD over 28 days was reduced, but mortality was higher at 28 days in patients treated with KGF, suggesting that it might exacerbate clinical outcomes in ARDS