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Within the H-site, the substrate analogue ( 12 ) interacts through hydrogen bonds to N108 and the backbone of V12, a interaction with F112, water bridges to R16 and Y175, and hydrophobic interactions with V12 and V115 (Fig

Consequently, alterations in cholesterol levels in immune cells may affect intercellular communication, receptor-mediated immune activation and downstream signaling pathways, among other processes ( 4.2.1 Lymphocytes In the cholesterol-rich tumor microenvironment, CD8 + T cells uptake and accumulate cholesterol after migrating to the tumor

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