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Reasons for discontinuation of obesity pharmacotherapy with semaglutide or Tirzepatide in clinical practice

Specifically, the method comprises the following steps: arg34GLP-1 (9-37) carries out the modification of the terminal amino group: 1g Boc-His (Boc) -Aib-OH was dissolved in 10mL of dichloromethane and 0.37g DIC was added

Keep a food diary to identify patterns

The logic is that bupropion + naltrexone (Contrave) addresses reward-driven eating and appetite, while topiramate independently suppresses cravings through a different brain mechanism