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In addition to well-established cerebrovascular and inflammatory mechanisms, emerging research highlights the gut microbiota's role in shaping stroke outcomes through the MGBA, influencing neuroinflammation, BBB integrity, and neuronal recovery (Wang et al., 2023a)

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Lack of critical involvement of caspase-3 in eryptosis has been emphasized in an extensive analysis of the caspase-3 contribution to eryptosis, which has revealed that eryptosis triggered in vitro by diverse compounds is not associated with caspase-3 recruitment in the majority of cases [84]

730 FtMt protein expression is significantly upregulated in MCAO/R mice, and the absence of FtMt promotes free iron deposition and lipid peroxidation, which aggravates ferroptosis and brain injury caused by MCAO/R