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Trial Registration The trials were registered at ClinicalTrials.gov (identifiers: NCT02054897, NCT01930188, NCT01885208, NCT01720446 and NCT02207374)

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Disruptions within this axis such as leptin resistance in obesity or impaired GLP-1 signaling in diabetes are not merely consequences of these diseases but active contributors to their pathogenesis by distorting taste preferences and perpetuating pathological eating behaviors

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Arginine builds collagen and increases blood flow to the injured site

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Lactate-lactylation hands between metabolic reprogramming and immunosuppression

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In highly alkaline solutions the doubly negative anion OOCCH(NH 2 )(CH 2 ) 2 COO prevails

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