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Despite these mechanistic differences, both drug classes consistently outperform many other therapeutic options in reducing anthropometric parameters such as body weight and body mass index

173 A trial that included 19 healthy field hockey players whose sleep was monitored by actigraphy found 200 mL (about 7 ounces) of tart cherry juice (equivalent to about 48 tart cherries), taken five times during a 48-hour period, resulted in increased time in bed, decreased wakefulness after sleep onset, and reduced nighttime movement compared with placebo juice consumption

Today, adjunctive therapies for type 1 diabetes that are not yet FDA approved include the glucose-lowering GLP-1s and SGLT-2s

Indeed, cells exhibit a graded increase in GLP-1 synthesis with increasing metabolic stress (16, 30, 67, 92, 94, 100103)