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The team hypothesizes that the variant alters the structure of the receptor protein, leading to higher expression of receptors on the cell surface and thus better drug binding

LC-MS/MS studies developed assays and confirmed detectability of metabolites in horse plasma/urine after administrationuseful as hard evidence of veterinary use, albeit in a doping-control context rather than therapy

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doi: 10.1136/annrheumdis-2013-204739