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While both products contain insulin glargine, their manufacturing processes and production cell lines differ, creating distinct structural variations that prevent automatic substitution at pharmacies

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Conen, D, Ke Wang, M, Popova, E, Chan, MT, Landoni, G, Cata, JP, Reimer, C, McLean, SR, Srinathan, S, Reyes, JT, Grande, AM, Tallada, AG, Sessler, DI, Fleischmann, E, Kabon, B, Voltolini, L, Cruz, P, Maziak, D, Gutirrez-Soriano, L, McIntyre, WF, Tandon, V, Martnez-Tllez, E, Guerra-Londono, JJ, DuMerton, D, Wong, RH, McGuire, AL, Kidane, B, Roux, DP, Shargall, Y, Wells, JR, Ofori, SN, Vincent, J, Xu, L, Li, Z, Eikelboom, JW, Jolly, SS, Healey, JS, Devereaux, PJ, Wang, MK, Wells, JR, Healey, JS, McIntyre, WF, Sessler, DI, Rajaram, R, Vaporciyan, AA, Mehran, RJ, Sepesi, B, Walsh, GL, Rice, DC, Swisher, SG

The attached antibodies were detected using horseradish-peroxidase-conjugated rabbit anti-hamster IgG antibody (Thermo Fisher Scientific