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Shortly after our publication, very much to our surprise, R254X was also found in 3 different countries as far as in Western Asia and Middle East.13-16 The research team in Lebanon followed our protocol and showed that R254X in Lebanon patients had the same haplotype as ours

This helps limit the entry of endotoxins such as LPS into the circulation and alleviates systemic inflammation

To illustrate, in reproductive health, GPx5 safeguards sperm from ROS during maturation, and deficiencies here have been linked to reduced fertility in animal models