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Lancet, 355(9203), 542-545

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DOI: 10.1002/14651858.CD015092.pub2 Tirzepatide for adults living with obesity by Juan VA Franco, Yang Guo, Lucia B Varela, Zakariya Aqra, Murad Alhalahla, Mauricio Medina Rodriguez, Edison Leonardo Salvador Oscco, Bernarda Patio Araujo, Susan Banda, Camila Micaela Escobar Liquitay, Javier Bracchiglione, Nicols Meza and Eva Madrid, 30 October 2025, Cochrane Database of Systematic Reviews

It amplifies the benefits of healthy habits and can disappoint if diet, sleep, and stress are ignored

But some lifestyle changes may help you control them: Limit caffeine, tobacco, and alcohol