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A physician discussing whether retatrutide is appropriate for you will take your baseline mood and motivation into account before recommending it

For patients already engaged in a comprehensive longevity program that includes metabolic monitoring, MOTS-c fits naturally into the toolkit

No office visits required

The FDA has approved three medications specifically for weight loss as of my preparation of this content: liraglutide (Saxenda), semaglutide (Wegovy), and tirzepatide (Zepbound) (National Institute of Diabetes and Digestive and Kidney Diseases, 2026b)

and glucagon-like pepetide-1 (GLP-1) and peptide YY (PYY), from L-cells (predominantly in the distal small and large intestine) (Figure 1)