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The mitochondrial toxins rotenone and 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), two PD-associated inhibitors of mitochondrial complex I, can induce PD-like phenotypes both in vitro and in vivo [13]

Amyotrophic lateral sclerosis and occupational exposures: a systematic literature review and meta-analyses

Archived from the original on February 6, 2013

Notably, studies have reported that DSIP-mediated analgesia occurs without the tolerance development typically seen with exogenous opioid compounds, suggesting a fundamentally different mechanism of interaction with the opioid system

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