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These usually occur during dose initiation and escalation and generally subside over time

Larger, well-designed clinical trials are needed to establish definitive recommendations, and current UK guidance does not support routine use

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In this context, it has been demonstrated that the restoration of -cell mass can occur not only through proliferation of existing -cells but also via transdifferentiation of other pancreatic cell types, such as -, -, PP-, and ductal epithelial cells (Figure 1B)

In saying this, it is important to recognize the innovations that are affordable, easy to use, and efficient