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Yes, small pilot studies have investigated intra-articular injection for knee osteoarthritis, with subjective pain improvement reported but no controlled trials completed

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In particular, a variant of approximately 20 kDa originated by an alternative splicing is present in a rather constant 1:9 ratio, [10] while recently an additional variant of ~ 23-24 kDa has also been reported in post-exercise states at higher proportions

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