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Mitochondria-mediated apoptosis is also called the intrinsic pathway and occurs in response to a wide range of death stimuli, and is characterized by cascade reactions including mitochondrial outer membrane permeabilization (MOMP), release of cytochrome c into the cytoplasm to activate caspase-9 and subsequent caspase-3 [5, 6]

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This acidic condition can destabilise copper peptides, possibly breaking down their formulation, making both ingredients less or ineffective